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TargetNADPH oxidase 4
LigandBDBM50330740
Substrate/Competitorn/a
Meas. Tech.ChEMBL_685143
Ki 65±n/a nM
Citation Laleu, BGaggini, FOrchard, MFioraso-Cartier, LCagnon, LHoungninou-Molango, SGradia, ADuboux, GMerlot, CHeitz, FSzyndralewiez, CPage, P First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis. J Med Chem53:7715-30 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
NADPH oxidase 4
Name:NADPH oxidase 4
Synonyms:KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | RENOX | Renal NAD(P)H-oxidase
Type:PROTEIN
Mol. Mass.:66954.54
Organism:Homo sapiens (Human)
Description:ChEMBL_792879
Residue:578
Sequence:
MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRAS
ASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHV
AAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTY
AIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLP
EYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLY
RYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCP
TETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEES
LNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLH
NKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGK
TVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50330740
NameBDBM50330740
Synonyms:2-(2-chlorophenyl)-4-((4-(3-methoxyphenyl)piperazin-1-yl)methyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione | CHEMBL1277767
TypeSmall organic molecule
Emp. Form.C25H26ClN5O3
Mol. Mass.479.959
SMILESCOc1cccc(c1)N1CCN(Cc2n(C)c(=O)cc3[nH]n(-c4ccccc4Cl)c(=O)c23)CC1
Structure
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n/a