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Target
NADPH oxidase 4
Ligand
BDBM50330746
Substrate
n/a
Meas. Tech.
ChEMBL_685143 (CHEMBL1286959)
Ki
128±n/a nM
Citation
 Laleu, B; Gaggini, F; Orchard, M; Fioraso-Cartier, L; Cagnon, L; Houngninou-Molango, S; Gradia, A; Duboux, G; Merlot, C; Heitz, F; Szyndralewiez, C; Page, P First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis. J Med Chem 53:7715-30 (2010) [PubMed]  Article 
Target
Name:
NADPH oxidase 4
Synonyms:
KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | NOX4_HUMAN | RENOX | Renal NAD(P)H-oxidase
Type:
PROTEIN
Mol. Mass.:
66954.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_792879
Residue:
578
Sequence:
MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHVAAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTYAIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLPEYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGKTVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
  
Inhibitor
Name:
BDBM50330746
Synonyms:
2-(2-chlorophenyl)-4-(2-fluorophenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione | CHEMBL1278018
Type:
Small organic molecule
Emp. Form.:
C19H13ClFN3O2
Mol. Mass.:
369.777
SMILES:
Cn1c(-c2ccccc2F)c2c(cc1=O)[nH]n(-c1ccccc1Cl)c2=O |(55.19,-34.39,;53.86,-35.16,;52.52,-34.4,;52.52,-32.86,;51.18,-32.11,;51.17,-30.57,;52.5,-29.78,;53.84,-30.55,;53.85,-32.09,;55.18,-32.86,;51.19,-35.17,;51.19,-36.71,;52.53,-37.49,;53.87,-36.71,;55.2,-37.48,;49.73,-37.19,;48.82,-35.94,;47.28,-35.94,;46.52,-37.27,;44.98,-37.28,;44.21,-35.94,;44.98,-34.6,;46.52,-34.6,;47.3,-33.27,;49.73,-34.7,;49.26,-33.23,)|
Structure:
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