Reaction Details Report a problem with these data
Target
Glycogen phosphorylase, muscle form
Ligand
BDBM50330796
Substrate
n/a
Meas. Tech.
ChEMBL_685480 (CHEMBL1285511)
Ki
4600±n/a nM
Citation
 Alexacou, KM; Tenchiu Deleanu, AC; Chrysina, ED; Charavgi, MD; Kostas, ID; Zographos, SE; Oikonomakos, NG; Leonidas, DD The binding ofß-d-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: A new class of inhibitors. Bioorg Med Chem 18:7911-22 (2010) [PubMed]  Article 
Target
Name:
Glycogen phosphorylase, muscle form
Synonyms:
Glycogen phosphorylase, muscle form | Muscle glycogen phosphorylase | Myophosphorylase | PYGM | PYGM_HUMAN
Type:
PROTEIN
Mol. Mass.:
97097.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1449751
Residue:
842
Sequence:
MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKISGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGHVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERMDWDKAWDVTVRTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEDFISDLDQLRKLLSFVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKREPNKFFVPRTVMIGGKAAPGYHMAKMIIRLVTAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDKLDQRGYNAQEYYDRIPELRQVIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEDYIKCQEKVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEAI
  
Inhibitor
Name:
BDBM50330796
Synonyms:
4-Fluoro-benzaldehyde4-(beta-D-glucopyranosyl)thiosemicarbazone | CHEMBL1277321
Type:
Small organic molecule
Emp. Form.:
C15H20FN3O4S
Mol. Mass.:
357.4
SMILES:
CC[C@H]1O[C@@H](NC(=S)NN=Cc2ccc(F)cc2)[C@H](O)[C@@H](O)[C@@H]1O |r,w:9.8|
Structure:
Search PDB for entries with ligand similarity: