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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50330966
Substrate
n/a
Meas. Tech.
ChEMBL_684105 (CHEMBL1286482)
EC50
869±n/a nM
Citation
 Zhang, J; Liu, X; Lei, X; Wang, L; Guo, L; Zhao, G; Lin, G Discovery and synthesis of novel luteolin derivatives as DAT agonists. Bioorg Med Chem 18:7842-8 (2010) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50330966
Synonyms:
2-(3,4-dihydroxyphenyl)-7-hydroxy-4-oxo-4H-chromen-5-ylpentanoate | CHEMBL1277423
Type:
Small organic molecule
Emp. Form.:
C20H18O7
Mol. Mass.:
370.3527
SMILES:
CCCCC(=O)Oc1cc(O)cc2oc(cc(=O)c12)-c1ccc(O)c(O)c1
Structure:
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