Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50330987
Substrate
n/a
Meas. Tech.
ChEMBL_684107 (CHEMBL1286484)
Ki
17±n/a nM
Citation
 Shook, BC; Rassnick, S; Osborne, MC; Davis, S; Westover, L; Boulet, J; Hall, D; Rupert, KC; Heintzelman, GR; Hansen, K; Chakravarty, D; Bullington, JL; Russell, R; Branum, S; Wells, KM; Damon, S; Youells, S; Li, X; Beauchamp, DA; Palmer, D; Reyes, M; Demarest, K; Tang, Y; Rhodes, K; Jackson, PF In vivo characterization of a dual adenosine A2A/A1 receptor antagonist in animal models of Parkinson's disease. J Med Chem 53:8104-15 (2010) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50330987
Synonyms:
2-amino-4-phenyl-8-(pyrrolidin-1-ylmethyl)-5H-indeno[1,2-d]pyrimidin-5-one dihydrochloride | CHEMBL1087189
Type:
Small organic molecule
Emp. Form.:
C22H20N4O
Mol. Mass.:
356.4204
SMILES:
Nc1nc2-c3cc(CN4CCCC4)ccc3C(=O)c2c(n1)-c1ccccc1
Structure:
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