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TargetEstradiol 17-beta-dehydrogenase 1 (17beta-HSD1)
LigandBDBM50330998
Substrate/Competitorn/a
Meas. Tech.ChEMBL_684635
IC50 6±n/a nM
Citation Oster, AHinsberger, SWerth, RMarchais-Oberwinkler, SFrotscher, MHartmann, RW Bicyclic substituted hydroxyphenylmethanones as novel inhibitors of 17ß-hydroxysteroid dehydrogenase type 1 (17ß-HSD1) for the treatment of estrogen-dependent diseases. J Med Chem53:8176-86 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1)
Name:Estradiol 17-beta-dehydrogenase 1
Synonyms:17-beta-HSD 1 | 17-beta-hydroxysteroid dehydrogenase type 1 | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | E2DH | Estradiol 17-beta-dehydrogenase 1 | Placental 17-beta-hydroxysteroid dehydrogenase
Type:Enzyme
Mol. Mass.:34945.13
Organism:Homo sapiens (Human)
Description:P14061
Residue:328
Sequence:
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL
ETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV
RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH
LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV
FLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGG
GAGPGAEDEAGRGAVGDPELGDPPAAPQ
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  Blast E-value cutoff:
BDBM50330998
NameBDBM50330998
Synonyms:(5-(2-fluoro-3-hydroxyphenyl)thiophen-2-yl)(3-hydroxyphenyl)methanone | CHEMBL1277617
TypeSmall organic molecule
Emp. Form.C17H11FO3S
Mol. Mass.314.331
SMILESOc1cccc(c1)C(=O)c1ccc(s1)-c1cccc(O)c1F
Structure
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