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Target
Nuclear factor NF-kappa-B p105 subunit
Ligand
BDBM50022178
Substrate
n/a
Meas. Tech.
ChEMBL_687291 (CHEMBL1291967)
IC50
200000±n/a nM
Citation
 Piccagli, L; Borgatti, M; Nicolis, E; Bianchi, N; Mancini, I; Lampronti, I; Vevaldi, D; Dall'Acqua, F; Cabrini, G; Gambari, R Virtual screening against nuclear factor¿B (NF-¿B) of a focus library: Identification of bioactive furocoumarin derivatives inhibiting NF-¿B dependent biological functions involved in cystic fibrosis. Bioorg Med Chem 18:8341-9 (2010) [PubMed]  Article 
Target
Name:
Nuclear factor NF-kappa-B p105 subunit
Synonyms:
NFKB1 | NFKB1_HUMAN | Nuclear factor NF-kappa-B (NF-kB) | Nuclear factor NF-kappa-B complex | Nuclear factor NF-kappa-B p105 subunit
Type:
Protein
Mol. Mass.:
105329.57
Organism:
Homo sapiens (Human)
Description:
P19838
Residue:
968
Sequence:
MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFHPGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGEVTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMATSWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQAHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQEGPLEGKI
  
Inhibitor
Name:
BDBM50022178
Synonyms:
4-Methyl-7-hydroxycoumarin | 4-methylumbelliferone | 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran | 7-Hydroxy-4-methyl-2-oxo-3-chromene | 7-Hydroxy-4-methyl-2H-1-benzopyran-2-one | 7-Hydroxy-4-methyl-2H-2-one (1) | 7-Hydroxy-4-methylcoumarin | 7-hydroxy-4-methyl-2H-chromen-2-one | CHEMBL12208 | Coumarin derivative, 3b | Imecromone | beta-Methylumbelliferone | cid_5280567
Type:
Small organic molecule
Emp. Form.:
C10H8O3
Mol. Mass.:
176.1687
SMILES:
Cc1cc(=O)oc2cc(O)ccc12
Structure:
Search PDB for entries with ligand similarity: