Reaction Details Report a problem with these data
Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM50331803
Substrate
n/a
Meas. Tech.
ChEMBL_686764 (CHEMBL1291003)
IC50
>20000±n/a nM
Citation
 Li, L; Berthelette, C; Chateauneuf, A; Ouellet, M; Sturino, CF; Wang, Z Potent and selective 5-LO inhibitor bearing benzothiophene pharmacophore: discovery of MK-5286. Bioorg Med Chem Lett 20:7440-3 (2010) [PubMed]  Article 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM50331803
Synonyms:
(S)-3-(4-fluorophenyl)-6-((4-(1,1,1-trifluoro-2-hydroxybutan-2-yl)-1H-1,2,3-triazol-1-yl)methyl)benzo[b]thiophene-2-carboxamide | CHEMBL1289558
Type:
Small organic molecule
Emp. Form.:
C22H18F4N4O2S
Mol. Mass.:
478.463
SMILES:
CC[C@](O)(c1cn(Cc2ccc3c(c(sc3c2)C(N)=O)-c2ccc(F)cc2)nn1)C(F)(F)F |r|
Structure:
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