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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50332127
Substrate
n/a
Meas. Tech.
ChEMBL_687950 (CHEMBL1291622)
IC50
27143±n/a nM
Citation
 Zhao, L; Zhang, Y; Dai, C; Guzi, T; Wiswell, D; Seghezzi, W; Parry, D; Fischmann, T; Siddiqui, MA Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors. Bioorg Med Chem Lett 20:7216-21 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50332127
Synonyms:
4-((1R,2R)-2-aminocyclohexylamino)-2-(4-chlorophenyl)thieno[3,2-c]pyridine-7-carboxamide | CHEMBL1288276
Type:
Small organic molecule
Emp. Form.:
C20H21ClN4OS
Mol. Mass.:
400.925
SMILES:
N[C@@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c2sc(cc12)-c1ccc(Cl)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: