Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM50021959
Substrate
n/a
Meas. Tech.
ChEMBL_696792 (CHEMBL1639005)
Ki
11000±n/a nM
Citation
 Papp-Wallace, KM; Taracila, M; Hornick, JM; Hujer, AM; Hujer, KM; Distler, AM; Endimiani, A; Bonomo, RA Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. Antimicrob Agents Chemother 54:2867-77 (2010) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
Class A carbapenemase KPC-2
Type:
PROTEIN
Mol. Mass.:
31116.99
Organism:
Escherichia coli
Description:
ChEMBL_696792
Residue:
293
Sequence:
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ
  
Inhibitor
Name:
BDBM50021959
Synonyms:
CHEMBL777 | MM 14151 | US9120808, Clavulanic acid potassium salt | antibiotic MM 14151 | clavulanic acid
Type:
Small organic molecule
Emp. Form.:
C8H9NO5
Mol. Mass.:
199.1608
SMILES:
OC\C=C1/O[C@@H]2CC(=O)N2[C@H]1C(O)=O |r|
Structure:
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