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Target
Nuclear receptor subfamily 1 group I member 2
Ligand
BDBM50333705
Substrate
n/a
Meas. Tech.
ChEMBL_700443 (CHEMBL1647982)
EC50
>30000±n/a nM
Citation
 Tyagarajan, S; Chakravarty, PK; Park, M; Zhou, B; Herrington, JB; Ratliff, K; Bugianesi, RM; Williams, B; Haedo, RJ; Swensen, AM; Warren, VA; Smith, M; Garcia, M; Kaczorowski, GJ; McManus, OB; Lyons, KA; Li, X; Madeira, M; Karanam, B; Green, M; Forrest, MJ; Abbadie, C; McGowan, E; Mistry, S; Jochnowitz, N; Duffy, JL A potent and selective indole N-type calcium channel (Ca(v)2.2) blocker for the treatment of pain. Bioorg Med Chem Lett 21:869-73 (2011) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 1 group I member 2
Synonyms:
NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1
Type:
Nuclear receptor
Mol. Mass.:
49774.77
Organism:
Homo sapiens (Human)
Description:
O75469
Residue:
434
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
  
Inhibitor
Name:
BDBM50333705
Synonyms:
CHEMBL1643731 | N-tert-butyl-2-(1-(2-(tert-butylamino)-2-oxoethyl)-2-(3-fluoro-5-(trifluoromethyl)phenyl)-1H-indol-5-yl)-2-methylpropanamide
Type:
Small organic molecule
Emp. Form.:
C29H35F4N3O2
Mol. Mass.:
533.6007
SMILES:
CC(C)(C)NC(=O)Cn1c(cc2cc(ccc12)C(C)(C)C(=O)NC(C)(C)C)-c1cc(F)cc(c1)C(F)(F)F
Structure:
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