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Target
Thioredoxin reductase 2, mitochondrial
Ligand
BDBM50240382
Substrate
n/a
Meas. Tech.
ChEMBL_700049 (CHEMBL1646826)
IC50
>200000±n/a nM
Citation
 Sorrentino, F; Karioti, A; Gratteri, P; Rigobello, MP; Scutari, G; Messori, L; Bindoli, A; Chioccioli, M; Gabbiani, C; Bergonzi, MC; Bilia, AR Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones. Bioorg Med Chem 19:631-41 (2011) [PubMed]  Article 
Target
Name:
Thioredoxin reductase 2, mitochondrial
Synonyms:
TRXR2_RAT | Trxr2 | Txnrd2
Type:
PROTEIN
Mol. Mass.:
56441.28
Organism:
Rattus norvegicus
Description:
ChEMBL_700049
Residue:
525
Sequence:
MAAIVAALRGSSGRFRPQTRVLTRGTRGAAGAASAAGGQQNFDLLVIGGGSGGLACAKEAAQLGRKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQAALLGGMIRDAQHYGWEVAQPVQHNWKAMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVNEHTVHGVDKAGKVTQLSAKHIVIATGGRPKYPTQVKGALEHGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSVPLRGFDQQMASLVTEHMESHGTRFLKGCVPSLIRKLPTNQLQVTWEDLASGKEDVGTFDTVLWAIGRVPETRNLNLEKAGVNTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMNYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHIEVYHAYYKPLEFTVADRDASQCYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIQCGASYAQVMQTVGIHPTCSEEVVKLHISKRSGLDPTVTGCG
  
Inhibitor
Name:
BDBM50240382
Synonyms:
1,4-Dihydroxyanthrachinon | 1,4-dihydroxy-9,10-anthraquinone | 1,4-dihydroxyanthra-9,10-quinone | 1,4-dihydroxyanthracene-9,10-dione | 1,4-dihydroxyanthraquinone | CHEMBL17594 | Chinizarin | quinizarin | quinizarine
Type:
Small organic molecule
Emp. Form.:
C14H8O4
Mol. Mass.:
240.2109
SMILES:
Oc1ccc(O)c2C(=O)c3ccccc3C(=O)c12
Structure:
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