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TargetC-X-C chemokine receptor type 4 (CXCR4)
LigandBDBM50333890
Substrate/Competitorn/a
Meas. Tech.ChEMBL_700061
IC50 1.3±n/a nM
Citation Skerlj, RBridger, GMcEachern, EHarwig, CSmith, CWilson, TVeale, DYee, HCrawford, JSkupinska, KWauthy, RYang, WZhu, YBogucki, DDi Fluri, MLangille, JHuskens, DDe Clercq, ESchols, D Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication. Bioorg Med Chem Lett21:262-6 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-X-C chemokine receptor type 4 (CXCR4)
Name:C-X-C chemokine receptor type 4
Synonyms:C-X-C chemokine receptor type 4 | CD_antigen=CD184 | CXC-R4 | CXCR-4 | FB22 | Fusin | HM89 | LCR1 | LESTR | Leukocyte-derived seven transmembrane domain receptor | NPYRL | SDF-1 receptor | Stromal cell-derived factor 1 receptor
Type:Enzyme
Mol. Mass.:39754.61
Organism:Homo sapiens (Human)
Description:P61073
Residue:352
Sequence:
MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVI
LVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNL
YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEA
DDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKT
TVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPI
LYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
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  Blast E-value cutoff:
BDBM50333890
NameBDBM50333890
Synonyms:CHEMBL1644092 | N-((1H-benzo[d]imidazol-2-yl)methyl)-N-((4-(aminomethyl)oxazol-5-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine
TypeSmall organic molecule
Emp. Form.C22H24N6O
Mol. Mass.388.4656
SMILESNCc1ncoc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc12
Structure
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n/a