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Target
Beta-carbonic anhydrase 1
Ligand
BDBM50334356
Substrate
n/a
Meas. Tech.
ChEMBL_700107 (CHEMBL1646989)
Ki
6.8±n/a nM
Citation
 Pacchiano, F; Carta, F; Vullo, D; Scozzafava, A; Supuran, CT Inhibition ofß-carbonic anhydrases with ureido-substituted benzenesulfonamides. Bioorg Med Chem Lett 21:102-5 (2010) [PubMed]  Article 
Target
Name:
Beta-carbonic anhydrase 1
Synonyms:
β-Carbonic anhydrase 1 (CA 1) | Carbonic Anhydrase (mtCA 1) | MTCA1_MYCTU | Uncharacterized protein Rv1284/MT1322 | canA | mtcA1
Type:
Enzyme
Mol. Mass.:
18186.06
Organism:
Mycobacterium tuberculosis
Description:
The recombinant GST-mtCA1 construct was cloned, expressed, and further purified from E. coli. The purified protein was used in inhibition assays.
Residue:
163
Sequence:
MTVTDDYLANNVDYASGFKGPLPMPPSKHIAIVACMDARLDVYRMLGIKEGEAHVIRNAGCVVTDDVIRSLAISQRLLGTREIILLHHTDCGMLTFTDDDFKRAIQDETGIRPTWSPESYPDAVEDVRQSLRRIEVNPFVTKHTSLRGFVFDVATGKLNEVTP
  
Inhibitor
Name:
BDBM50334356
Synonyms:
4-(3-(4-iodophenyl)ureido)benzenesulfonamide | 4-{[(4'-Iodophenyl)carbamoyl]amino}benzenesulfonamide | CHEMBL1643292
Type:
Small organic molecule
Emp. Form.:
C13H12IN3O3S
Mol. Mass.:
417.222
SMILES:
NS(=O)(=O)c1ccc(NC(=O)Nc2ccc(I)cc2)cc1
Structure:
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