Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-6
Ligand
BDBM50119774
Substrate
n/a
Meas. Tech.
ChEMBL_701134 (CHEMBL1648232)
IC50
2±n/a nM
Citation
 Zhang, Z; Zheng, G; Pivavarchyk, M; Deaciuc, AG; Dwoskin, LP; Crooks, PA Novel bis-, tris-, and tetrakis-tertiary amino analogs as antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release. Bioorg Med Chem Lett 21:88-91 (2010) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-6
Synonyms:
ACHA6_RAT | Acra6 | Chrna6 | Neuronal acetylcholine receptor protein alpha-6 subunit | Neuronal acetylcholine receptor subunit alpha-6 | Neuronal acetylcholine receptor subunit alpha-6/beta-3
Type:
PROTEIN
Mol. Mass.:
56943.53
Organism:
Rattus norvegicus
Description:
ChEMBL_1454451
Residue:
493
Sequence:
MLNGWGRGDLRSGLCLWICGFLAFFKGSRGCVSEEQLFHTLFAHYNRFIRPVENVSDPVTVHFELAITQLANVDEVNQIMETNLWLRHVWKDYRLCWDPTEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATHTMPKWVKTMFLQVFPSILMMRRPLDKTKEMDGVKDPKTHTKRPAKVKFTHRKEPKLLKECRHCHKSSEIAPGKRLSQQPAQWVTENSEHPPDVEDVIDSVQFIAENMKSHNETKEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVGLFLQPLLGNTGAS
  
Inhibitor
Name:
BDBM50119774
Synonyms:
1,1'-(dodecane-1,12-diyl)bis(3-methylpyridinium)bromide | 1,12-di(3-methyl-1-pyridiniumyl)dodecane; with dibromide ions | 3-methyl-1-[6-(3-methylpyridinium-1-yl)dodecyl]pyridinium; Dibromide | CHEMBL54331 | N,N'-(1,12-dodecandiyl)-bis-pyridinium dibromide | N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide | N,N'-dodecane-1,12-diyl-bis-3-picoliniumdibromide | N,N'-dodecane-1,12-yl-bis-3-picolinium dibromide | N,N'-dodecylbis-picolinium bromide | mono(1,1'-(dodecane-1,12-diyl)bis(3-methylpyridinium))dibromide
Type:
Small organic molecule
Emp. Form.:
C24H38N2
Mol. Mass.:
354.5708
SMILES:
Cc1ccc[n+](CCCCCCCCCCCC[n+]2cccc(C)c2)c1
Structure:
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