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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50334789
Substrate
n/a
Meas. Tech.
ChEMBL_699332 (CHEMBL1647250)
IC50
71±n/a nM
Citation
 Yao, Z; Xu, Y; Zhang, M; Jiang, S; Nicklaus, MC; Liao, C Discovery of a novel hybrid from finasteride and epristeride as 5a-reductase inhibitor. Bioorg Med Chem Lett 21:475-8 (2010) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50334789
Synonyms:
(4aS,4bR,10aR,10bS,12aS)-10a,12a-dimethyl-2-oxo-1,2,3,4,4a,4b,5,9,10,10a,10b,11,12,12a-tetradecahydronaphtho[2,1-f]quinoline-8-carboxylic acid | CHEMBL1642918
Type:
Small organic molecule
Emp. Form.:
C20H27NO3
Mol. Mass.:
329.4333
SMILES:
C[C@]12CC[C@H]3[C@@H](CC=C4C=C(CC[C@]34C)C(O)=O)[C@@H]1CCC(=O)N2 |r,c:9,t:7|
Structure:
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