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Target
Lysosomal alpha-glucosidase
Ligand
BDBM50335395
Substrate
n/a
Meas. Tech.
ChEMBL_701785 (CHEMBL1656922)
IC50
>1000000±n/a nM
Citation
 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars ACS Med Chem Lett 2:119-123 (2011) [PubMed]  Article 
Target
Name:
Lysosomal alpha-glucosidase
Synonyms:
α-Glucosidase | Acid maltase | Gaa | LYAG_MOUSE | Lysosomal alpha-glucosidase | alpha-glucosidase (Gaa)
Type:
Enzyme
Mol. Mass.:
106235.32
Organism:
Mus musculus (Mouse)
Description:
P70699
Residue:
953
Sequence:
MNIRKPLCSNSVVGACTLISLTTAVILGHLMLRELMLLPQDLHESSSGLWKTYRPHHQEGYKPGPLHIQEQTEQPKEAPTQCDVPPSSRFDCAPDKGISQEQCEARGCCYVPAGQVLKEPQIGQPWCFFPPSYPSYRLENLSSTESGYTATLTRTSPTFFPKDVLTLQLEVLMETDSRLHFKIKDPASKRYEVPLETPRVLSQAPSPLYSVEFSEEPFGVIVRRKLGGRVLLNTTVAPLFFADQFLQLSTSLPSQHITGLGEHLSPLMLSTDWARITLWNRDTPPSQGTNLYGSHPFYLALEDGGLAHGVFLLNSNAMDVILQPSPALTWRSTGGILDVYVFLGPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAIVRQVVENMTRTHFPLDVQWNDLDYMDARRDFTFNQDSFADFPDMVRELHQDGRRYMMIVDPAISSAGPAGSYRPYDEGLRRGVFITNETGQPLIGKVWPGTTAFPDFTNPETLDWWQDMVSEFHAQVPFDGMWLDMNEPSNFVRGSQQGCPNNELENPPYVPGVVGGILQAATICASSHQFLSTHYNLHNLYGLTEAIASSRALVKTRGTRPFVISRSTFSGHGRYAGHWTGDVRSSWEHLAYSVPDILQFNLLGVPLVGADICGFIGDTSEELCVRWTQLGAFYPFMRNHNDLNSVPQEPYRFSETAQQAMRKAFALRYALLPYLYTLFHRAHVRGDTVARPLFLEFPEDPSTWSVDRQLLWGPALLITPVLEPGKTEVTGYFPKGTWYNMQMVSVDSLGTLPSPSSASSFRSAVQSKGQWLTLEAPLDTINVHLREGYIIPLQGPSLTTTESRKQPMALAVALTASGEADGELFWDDGESLAVLERGAYTLVTFSAKNNTIVNKLVRVTKEGAELQLREVTVLGVATAPTQVLSNGIPVSNFTYSPDNKSLAIPVSLLMGELFQISWS
  
Inhibitor
Name:
BDBM50335395
Synonyms:
CHEMBL1651555 | N-Heptyl-L-ido-1-deoxynojirimycin
Type:
Small organic molecule
Emp. Form.:
C13H27NO4
Mol. Mass.:
261.3578
SMILES:
CCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO |r|
Structure:
Search PDB for entries with ligand similarity: