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Target
Type-1 angiotensin II receptor
Ligand
BDBM50049183
Substrate
n/a
Meas. Tech.
ChEMBL_717323 (CHEMBL1669992)
Kd
1.51±n/a nM
Citation
 Naik, P; Murumkar, P; Giridhar, R; Yadav, MR Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective. Bioorg Med Chem 18:8418-56 (2010) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50049183
Synonyms:
2,7-Diethyl-5-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-5H-pyrazolo[1,5-b][1,2,4]triazole | CHEMBL347610 | YM-358
Type:
Small organic molecule
Emp. Form.:
C22H22N8
Mol. Mass.:
398.4637
SMILES:
CCc1nc2c(CC)cn(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)n2n1
Structure:
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