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Target
Multidrug resistance protein MdtK
Ligand
BDBM50105463
Substrate
n/a
Meas. Tech.
ChEMBL_720698 (CHEMBL1681165)
Kd
9800±n/a nM
Citation
 Long, F; Rouquette-Loughlin, C; Shafer, WM; Yu, EW Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. Antimicrob Agents Chemother 52:3052-60 (2008) [PubMed]  Article 
Target
Name:
Multidrug resistance protein MdtK
Synonyms:
MDTK_ECOLI | Multidrug-efflux transporter | mdtK | norE | norM | ydhE
Type:
PROTEIN
Mol. Mass.:
49460.10
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_720698
Residue:
457
Sequence:
MQKYISEARLLLALAIPVILAQIAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRERIAHQVRQGFWLAGFVSVLIMLVLWNAGYIIRSMENIDPALADKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLLVNIPVNYIFIYGHFGMPELGGVGCGVATAAVYWVMFLAMVSYIKRARSMRDIRNEKGTAKPDPAVMKRLIQLGLPIALALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPMSLAAAVTIRVGYRLGQGSTLDAQTAARTGLMVGVCMATLTAIFTVSLREQIALLYNDNPEVVTLAAHLMLLAAVYQISDSIQVIGSGILRGYKDTRSIFYITFTAYWVLGLPSGYILALTDLVVEPMGPAGFWIGFIIGLTSAAIMMMLRMRFLQRLPSAIILQRASR
  
Inhibitor
Name:
BDBM50105463
Synonyms:
2,7-diamino-10-ethyl-9-phenylphenanthridinium bromide | 2,7-diamino-9-phenyl-10-ethylphenanthridinium bromide | 3,8-diamino-5-ethyl-6-phenylphenanthridinium bromide | CHEMBL284328 | Dromilac | EtBr | Ethidium bromide | Homidium bromide
Type:
Small organic molecule
Emp. Form.:
C21H20N3
Mol. Mass.:
314.4031
SMILES:
CCn1c(-c2ccccc2)c2cc(N)ccc2c2ccc(=[NH2+])cc12
Structure:
Search PDB for entries with ligand similarity: