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Target
DNA polymerase subunit gamma-1
Ligand
BDBM50336503
Substrate
n/a
Meas. Tech.
ChEMBL_720298 (CHEMBL1679164)
IC50
>100000±n/a nM
Citation
 Nyanguile, O; Pauwels, F; Van den Broeck, W; Boutton, CW; Quirynen, L; Ivens, T; van der Helm, L; Vandercruyssen, G; Mostmans, W; Delouvroy, F; Dehertogh, P; Cummings, MD; Bonfanti, JF; Simmen, KA; Raboisson, P 1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors. Antimicrob Agents Chemother 52:4420-31 (2008) [PubMed]  Article 
Target
Name:
DNA polymerase subunit gamma-1
Synonyms:
DNA Polymerase gamma | DNA nucleotidylexotransferase | DNA polymerase (alpha/delta/epsilon) | DNA polymerase beta | DNA polymerase delta subunit 1 | DNA polymerase eta | DNA polymerase gamma subunit 1 | DNA polymerase iota | DNA polymerase kappa | DNA polymerase lambda | DNA polymerase subunit gamma-1 | DNA-directed DNA/RNA polymerase mu | DPOG1_HUMAN | MDP1 | Mitochondrial DNA polymerase catalytic subunit | POLG | POLG1 | POLGA | PolG-alpha
Type:
Enzyme Subunit
Mol. Mass.:
139566.98
Organism:
Homo sapiens (Human)
Description:
Enzyme was purchased from Ulrich Hubscher, University of Zurich-Irchel, Switzerland.
Residue:
1239
Sequence:
MSRLLWRKVAGATVGPGPVPAPGRWVSSSVPASDPSDGQRRRQQQQQQQQQQQQQPQQPQVLSSEGGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQPAVPLPDVELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTRYGPEGEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSQRLVEERYSWTSQLSPADLIPLEVPTGASSPTQRDWQEQLVVGHNVSFDRAHIREQYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWIAAKQGKHKVQPPTKQGQKSQRKARRGPAISSWDWLDISSVNSLAEVHRLYVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCAQDVWATHEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLAEAQGTYEELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDPMDQEDLGPCSEEEEFQQDVMARACLQKLKGTTELLPKRPQHLPGHPGWYRKLCPRLDDPAWTPGPSLLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLVPGRRDNLAKLPTGTTLESAGVVCPYRAIESLYRKHCLEQGKQQLMPQEAGLAEEFLLTDNSAIWQTVEELDYLEVEAEAKMENLRAAVPGQPLALTARGGPKDTQPSYHHGNGPYNDVDIPGCWFFKLPHKDGNSCNVGSPFAKDFLPKMEDGTLQAGPGGASGPRALEINKMISFWRNAHKRISSQMVVWLPRSALPRAVIRHPDYDEEGLYGAILPQVVTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQAPPGYTLVGADVDSQELWIAAVLGDAHFAGMHGCTAFGWMTLQGRKSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQPFAERLLMQFNHRLTQQEAAEKAQQMYAATKGLRWYRLSDEGEWLVRELNLPVDRTEGGWISLQDLRKVQRETARKSQWKKWEVVAERAWKGGTESEMFNKLESIATSDIPRTPVLGCCISRALEPSAVQEEFMTSRVNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYLVREEDRYRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDRCLRKEVTMDCKTPSNPTGMERRYGIPQGEALDIYQIIELTKGSLEKRSQPGP
  
Inhibitor
Name:
BDBM50336503
Synonyms:
10-acetyl-11-(3-(benzyloxy)-4-methoxyphenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one | CHEMBL1673156
Type:
Small organic molecule
Emp. Form.:
C31H32N2O4
Mol. Mass.:
496.5968
SMILES:
COc1ccc(cc1OCc1ccccc1)C1C2C(=O)CC(C)(C)CC2=Nc2ccccc2N1C(C)=O |c:28|
Structure:
Search PDB for entries with ligand similarity: