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TargetDihydrofolate Reductase (DHFR)
LigandBDBM50335530
Substrate/Competitorn/a
Meas. Tech.ChEMBL_723694
Ki 0.9±n/a nM
Citation Bourne, CRBarrow, EWBunce, RABourne, PCBerlin, KDBarrow, WW Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. Antimicrob Agents Chemother54:3825-33 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate Reductase (DHFR)
Name:Dihydrofolate reductase
Synonyms:Dihydrofolate reductase (DfrB) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:18249.71
Organism:Staphylococcus aureus
Description:n/a
Residue:159
Sequence:
MTLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRN
VVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRG
DTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRKK
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BDBM50335530
NameBDBM50335530
Synonyms:(S)-3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2,3-dimethoxyphenyl)-1-(1-propylphthalazin-2(1H)-yl)prop-2-en-1-one | (S,E)-3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2,3-dimethoxyphenyl)-1-(1-propylphthalazin-2(1H)-yl)prop-2-en-1-one | 5-(3,4-dimethoxy-5-{(1E)-3-oxo-3-[(1S)-1-propylphthalazin-2(1H)-yl]prop-1-en-1-yl}benzyl)pyrimidine-2,4-diamine | CHEMBL1235617
TypeSmall organic molecule
Emp. Form.C27H30N6O3
Mol. Mass.486.5655
SMILESCCC[C@@H]1N(N=Cc2ccccc12)C(=O)\C=C\c1cc(Cc2cnc(N)nc2N)cc(OC)c1OC |r,c:5|
Structure
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n/a