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Target
Phosphodiesterase
Ligand
BDBM50336526
Substrate
n/a
Meas. Tech.
ChEMBL_723718 (CHEMBL1677388)
IC50
>10000±n/a nM
Citation
 King-Keller, S; Li, M; Smith, A; Zheng, S; Kaur, G; Yang, X; Wang, B; Docampo, R Chemical validation of phosphodiesterase C as a chemotherapeutic target in Trypanosoma cruzi, the etiological agent of Chagas' disease. Antimicrob Agents Chemother 54:3738-45 (2010) [PubMed]  Article 
Target
Name:
Phosphodiesterase
Synonyms:
Cyclic nucleotide specific phosphodiesterase | Phosphodiesterase (TcrPDEC)
Type:
Protein
Mol. Mass.:
103074.59
Organism:
Trypanosoma cruzi
Description:
Q53I59
Residue:
924
Sequence:
MSEDAGLPVPRSQWVERGVSCATCGKRFSLFTAKSNCPCCGKLCCSDCVQAECAIVGGSAPSKVCIDCFSMLQSRRRVEPDEGSSFREFNAASAFPLQTRLLADGRVESGETSRVSPPNDGRVQHVSRANGYSNSLPVLDEYVDDLLRKSELLRMENDVLLNRLREQEAEIHALRLERDRAVARIVPDGGSMAGRSGLPQVSDEIVKELRGELAVAHLRIESVKRELKNALDRAKSSETMVRNLKQGLCNYKEEVVRPLQSREEVEMLPGVNGRRDMISTRRLPPSIVQDTILAVVPPKSCAAIGTDVDLRDWGFDTFEVASRVPSVLQSVAMHVALAWNFFASQEEAQKWAFLVAAVENNYRPNPYHNAIHAADVLQGTFSLVSAAKPLMEHLTPLECKAAAFAALTHDVCHPGRTNAFLAAVQDPVSFKFSGKGTLEQLHTVTAFELLNVTEFDFTSSMDNASFLEFKNIVSHLIGHTDMSLHSETIAKHGAKLSAGGFDCTCKEDRLEALSLLLHAADIGASSRGVAIARKWLVILQEFADQAEDERRRGLPVTPGFDTPSSVEKSQIPFLDFFVIPTFDLLHQLFPSIEEPLHNLRKLRELYAAKAGVTTPFPPPVDYRSREERIRSLEAELAYFRRREEEFHRQLQELRTASENENKSSAAPMTREGALNKQSQLVCRGEGNMNADWADAGGGFRNGKDVRDLQDVSMDHLVSSKTVESDTGDSGPRGRRGSKAETTKAYERKLGEREAALMATARLLENREKRLAVFSEKLAEIAEGLHEERKRLQPMEEFKTPCFSRETELISEESASMDVTHRFSTQWEAEERLARKYRELDELLLIVRAMRMGYAARRNTNLGWKALSATLAEREAAISEAVELSRQRRRHLEEGRGPHPTATHLDRLENATFQLMSAITLLTQC
  
Inhibitor
Name:
BDBM50336526
Synonyms:
1-(benzo[b]thiophen-3-yl)-3-(2,3-dihydro-1H-inden-2-yl)urea | CHEMBL1673319
Type:
Small organic molecule
Emp. Form.:
C18H16N2OS
Mol. Mass.:
308.397
SMILES:
O=C(NC1Cc2ccccc2C1)Nc1csc2ccccc12
Structure:
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