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Target
Phosphodiesterase
Ligand
BDBM50273510
Substrate
n/a
Meas. Tech.
ChEMBL_723718 (CHEMBL1677388)
IC50
3500±n/a nM
Citation
 King-Keller, S; Li, M; Smith, A; Zheng, S; Kaur, G; Yang, X; Wang, B; Docampo, R Chemical validation of phosphodiesterase C as a chemotherapeutic target in Trypanosoma cruzi, the etiological agent of Chagas' disease. Antimicrob Agents Chemother 54:3738-45 (2010) [PubMed]  Article 
Target
Name:
Phosphodiesterase
Synonyms:
Cyclic nucleotide specific phosphodiesterase | Phosphodiesterase (TcrPDEC)
Type:
Protein
Mol. Mass.:
103074.59
Organism:
Trypanosoma cruzi
Description:
Q53I59
Residue:
924
Sequence:
MSEDAGLPVPRSQWVERGVSCATCGKRFSLFTAKSNCPCCGKLCCSDCVQAECAIVGGSAPSKVCIDCFSMLQSRRRVEPDEGSSFREFNAASAFPLQTRLLADGRVESGETSRVSPPNDGRVQHVSRANGYSNSLPVLDEYVDDLLRKSELLRMENDVLLNRLREQEAEIHALRLERDRAVARIVPDGGSMAGRSGLPQVSDEIVKELRGELAVAHLRIESVKRELKNALDRAKSSETMVRNLKQGLCNYKEEVVRPLQSREEVEMLPGVNGRRDMISTRRLPPSIVQDTILAVVPPKSCAAIGTDVDLRDWGFDTFEVASRVPSVLQSVAMHVALAWNFFASQEEAQKWAFLVAAVENNYRPNPYHNAIHAADVLQGTFSLVSAAKPLMEHLTPLECKAAAFAALTHDVCHPGRTNAFLAAVQDPVSFKFSGKGTLEQLHTVTAFELLNVTEFDFTSSMDNASFLEFKNIVSHLIGHTDMSLHSETIAKHGAKLSAGGFDCTCKEDRLEALSLLLHAADIGASSRGVAIARKWLVILQEFADQAEDERRRGLPVTPGFDTPSSVEKSQIPFLDFFVIPTFDLLHQLFPSIEEPLHNLRKLRELYAAKAGVTTPFPPPVDYRSREERIRSLEAELAYFRRREEEFHRQLQELRTASENENKSSAAPMTREGALNKQSQLVCRGEGNMNADWADAGGGFRNGKDVRDLQDVSMDHLVSSKTVESDTGDSGPRGRRGSKAETTKAYERKLGEREAALMATARLLENREKRLAVFSEKLAEIAEGLHEERKRLQPMEEFKTPCFSRETELISEESASMDVTHRFSTQWEAEERLARKYRELDELLLIVRAMRMGYAARRNTNLGWKALSATLAEREAAISEAVELSRQRRRHLEEGRGPHPTATHLDRLENATFQLMSAITLLTQC
  
Inhibitor
Name:
BDBM50273510
Synonyms:
1-[4-Difluoromethoxy-3-(pyridin-2-yloxy)phenyl]butan-1-one | CHEMBL458296
Type:
Small organic molecule
Emp. Form.:
C16H15F2NO3
Mol. Mass.:
307.292
SMILES:
CCCC(=O)c1ccc(OC(F)F)c(Oc2ccccn2)c1
Structure:
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