Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50336639
Substrate
n/a
Meas. Tech.
ChEMBL_726067 (CHEMBL1678663)
pH
7.5±n/a
Ki
10±n/a nM
Comments
extracted
Citation
 Joseph, P; Ouahrani-Bettache, S; Montero, JL; Nishimori, I; Minakuchi, T; Vullo, D; Scozzafava, A; Winum, JY; Köhler, S; Supuran, CT A newß-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth. Bioorg Med Chem 19:1172-8 (2011) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50336639
Synonyms:
4-((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-ylamino)benzenesulfonamide | CHEMBL1672445
Type:
Small organic molecule
Emp. Form.:
C12H18N2O6S
Mol. Mass.:
318.346
SMILES:
C[C@@H]1O[C@@H](Nc2ccc(cc2)S(N)(=O)=O)[C@H](O)[C@H](O)[C@H]1O |r|
Structure:
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