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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50337322
Substrate
n/a
Meas. Tech.
ChEMBL_726512 (CHEMBL1685407)
Ki
20307±n/a nM
Citation
 Akritopoulou-Zanze, I; Wakefield, BD; Gasiecki, A; Kalvin, D; Johnson, EF; Kovar, P; Djuric, SW Scaffold oriented synthesis. Part 3: design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing [2+3] cycloadditions. Bioorg Med Chem Lett 21:1476-9 (2011) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50337322
Synonyms:
5-(1-(2,3-dichlorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-indazole | CHEMBL1682354
Type:
Small organic molecule
Emp. Form.:
C16H11Cl2N5
Mol. Mass.:
344.198
SMILES:
Clc1cccc(Cn2cc(nn2)-c2ccc3[nH]ncc3c2)c1Cl
Structure:
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