Reaction Details Report a problem with these data
Target
Prostaglandin D2 receptor 2
Ligand
BDBM50338158
Substrate
n/a
Meas. Tech.
ChEMBL_727759 (CHEMBL1686118)
IC50
31000±n/a nM
Citation
 Bonafoux, D; Abibi, A; Bettencourt, B; Burchat, A; Ericsson, A; Harris, CM; Kebede, T; Morytko, M; McPherson, M; Wallace, G; Wu, X Thienopyrrole acetic acids as antagonists of the CRTH2 receptor. Bioorg Med Chem Lett 21:1861-4 (2011) [PubMed]  Article 
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:
Enzyme
Mol. Mass.:
43295.45
Organism:
Homo sapiens (Human)
Description:
Q9Y5Y4
Residue:
395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
  
Inhibitor
Name:
BDBM50338158
Synonyms:
2-(5-methyl-6-(4-(methylsulfonyl)benzyl)-6H-thieno[2,3-b]pyrrol-4-yl)acetic acid | CHEMBL1684727
Type:
Small organic molecule
Emp. Form.:
C17H17NO4S2
Mol. Mass.:
363.451
SMILES:
Cc1c(CC(O)=O)c2ccsc2n1Cc1ccc(cc1)S(C)(=O)=O
Structure:
Search PDB for entries with ligand similarity: