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Target
NADP-dependent malic enzyme
Ligand
BDBM50338502
Substrate
n/a
Meas. Tech.
ChEMBL_728315 (CHEMBL1687575)
Ki
57000±n/a nM
Citation
 Hou, S; Liu, W; Ji, D; Zhao, ZK Efficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme. Bioorg Med Chem Lett 21:1667-9 (2011) [PubMed]  Article 
Target
Name:
NADP-dependent malic enzyme
Synonyms:
MAO2_ECOLI | NADP-ME | maeB | ypfF
Type:
PROTEIN
Mol. Mass.:
82404.36
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_728315
Residue:
759
Sequence:
MDDQLKQSALDFHEFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIEKDPLKAYKYTARGNLVAVISNGTAVLGLGNIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDELDPDKFIEVVAALEPTFGGINLEDIKAPECFYIEQKLRERMNIPVFHDDQHGTAIISTAAILNGLRVVEKNISDVRMVVSGAGAAAIACMNLLVALGLQKHNIVVCDSKGVIYQGREPNMAETKAAYAVVDDGKRTLDDVIEGADIFLGCSGPKVLTQEMVKKMARAPMILALANPEPEILPPLAKEVRPDAIICTGRSDYPNQVNNVLCFPFIFRGALDVGATAINEEMKLAAVRAIAELAHAEQSEVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAAMESGVATRPIADFDVYIDKLTEFVYKTNLFMKPIFSQARKAPKRVVLPEGEEARVLHATQELVTLGLAKPILIGRPNVIEMRIQKLGLQIKAGVDFEIVNNESDPRFKEYWTEYFQIMKRRGVTQEQAQRALISNPTVIGAIMVQRGEADAMICGTVGDYHEHFSVVKNVFGYRDGVHTAGAMNALLLPSGNTFIADTYVNDEPDAEELAEITLMAAETVRRFGIEPRVALLSHSNFGSSDCPSSSKMRQALELVRERAPELMIDGEMHGDAALVEAIRNDRMPDSSLKGSANILVMPNMEAARISYNLLRVSSSEGVTVGPVLMGVAKPVHVLTPIASVRRIVNMVALAVVEAQTQPL
  
Inhibitor
Name:
BDBM50338502
Synonyms:
5-O-phosphate-1-N-(4'-(4''-methoxyhenyl))-[1',2',3']-triazol-beta-D-ribofuranoside | CHEMBL1683319
Type:
Small organic molecule
Emp. Form.:
C14H18N3O8P
Mol. Mass.:
387.2818
SMILES:
COc1ccc(cc1)-c1cn(nn1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Structure:
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