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Target
Vasopressin V1b receptor
Ligand
BDBM50338811
Substrate
n/a
Meas. Tech.
ChEMBL_727040 (CHEMBL1686964)
IC50
6±n/a nM
Citation
 Napier, SE; Letourneau, JJ; Ansari, N; Auld, DS; Baker, J; Best, S; Campbell-Wan, L; Chan, JH; Craighead, M; Desai, H; Goan, KA; Ho, KK; Hulskotte, EG; MacSweeney, CP; Milne, R; Morphy, JR; Neagu, I; Ohlmeyer, MH; Peeters, AW; Presland, J; Riviello, C; Ruigt, GS; Thomson, FJ; Zanetakos, HA; Zhao, J; Webb, ML Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists. Bioorg Med Chem Lett 21:1871-5 (2011) [PubMed]  Article 
Target
Name:
Vasopressin V1b receptor
Synonyms:
AVPR V1b | AVPR V3 | AVPR1B | AVPR3 | Antidiuretic hormone receptor 1b | V1BR_HUMAN | V1bR | VASOPRESSIN V1B | VPR3 | Vasopressin V1b receptor | Vasopressin V1b receptor (V1b) | Vasopressin V3 | Vasopressin V3 receptor
Type:
Enzyme
Mol. Mass.:
46985.01
Organism:
Homo sapiens (Human)
Description:
P47901
Residue:
424
Sequence:
MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAETIIF
  
Inhibitor
Name:
BDBM50338811
Synonyms:
2-(2-(3-chlorophenyl)-4-oxo-6-(3-(piperidin-1-yl)propoxy)quinazolin-3(4H)-yl)-N-isopropylacetamide | CHEMBL1684574
Type:
Small organic molecule
Emp. Form.:
C27H33ClN4O3
Mol. Mass.:
497.029
SMILES:
CC(C)NC(=O)Cn1c(nc2ccc(OCCCN3CCCCC3)cc2c1=O)-c1cccc(Cl)c1
Structure:
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