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Target
Signal transducer and activator of transcription 3
Ligand
BDBM50338999
Substrate
n/a
Meas. Tech.
ChEMBL_729310 (CHEMBL1695665)
IC50
75000±n/a nM
Citation
 Masuda, Y; Sato, H; Takahashi, O; Yokotagawa, T; Furuya, T; Okawara, T; Otsuka, M; Ogo, N; Ashizawa, T; Oshita, C; Tai, S; Ishii, H; Akiyama, Y; Asai, A. Identification of a New Series of STAT3 Inhibitors by Virtual Screening. ACS Med Chem Lett 1:371-375 (2010) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 3
Synonyms:
APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3)
Type:
Protein
Mol. Mass.:
88064.31
Organism:
Homo sapiens (Human)
Description:
P40763
Residue:
770
Sequence:
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
  
Inhibitor
Name:
BDBM50338999
Synonyms:
2-Phenyl-N-[5-(2-thienyl)-1,3,4-oxadiazol-2-yl)-4-quinolinecarboxamide | CHEMBL1562195 | cid_2104460
Type:
Small organic molecule
Emp. Form.:
C22H14N4O2S
Mol. Mass.:
398.437
SMILES:
O=C(Nc1nnc(o1)-c1cccs1)c1cc(nc2ccccc12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: