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Target
Glutathione reductase, mitochondrial
Ligand
BDBM50339128
Substrate
n/a
Meas. Tech.
ChEMBL_729212 (CHEMBL1694676)
IC50
26700±n/a nM
Citation
 Sturm, N; Hu, Y; Zimmermann, H; Fritz-Wolf, K; Wittlin, S; Rahlfs, S; Becker, K Compounds structurally related to ellagic acid show improved antiplasmodial activity. Antimicrob Agents Chemother 53:622-30 (2009) [PubMed]  Article 
Target
Name:
Glutathione reductase, mitochondrial
Synonyms:
GLUR | GRD1 | GSHR_HUMAN | GSR | Glutathione reductase | Glutathione reductase (GR)
Type:
Enzyme
Mol. Mass.:
56271.52
Organism:
Homo sapiens (Human)
Description:
P00390
Residue:
522
Sequence:
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
  
Inhibitor
Name:
BDBM50339128
Synonyms:
CHEMBL1688543 | Flavellagic acid
Type:
Small organic molecule
Emp. Form.:
C14H6O9
Mol. Mass.:
318.192
SMILES:
Oc1cc2c3c(oc(=O)c4c(O)c(O)c(O)c(oc2=O)c34)c1O
Structure:
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