Reaction Details Report a problem with these data
Target
Placenta growth factor
Ligand
BDBM50339209
Substrate
n/a
Meas. Tech.
ChEMBL_736117 (CHEMBL1692900)
Kd
0.3±n/a nM
Citation
 Bower, KE; Lam, SN; Oates, BD; Del Rosario, JR; Corner, E; Osothprarop, TF; Kinhikar, AG; Hoye, JA; Preston, RR; Murphy, RE; Campbell, LA; Huang, H; Jimenez, J; Cao, X; Chen, G; Ainekulu, ZW; Datt, AB; Levin, NJ; Doppalapudi, VR; Pirie-Shepherd, SR; Bradshaw, C; Woodnutt, G; Lappe, RW Evolution of potent and stable placental-growth-factor-1-targeting CovX-bodies from phage display peptide discovery. J Med Chem 54:1256-65 (2011) [PubMed]  Article 
Target
Name:
Placenta growth factor
Synonyms:
PGF | PGFL | PLGF | PLGF_HUMAN
Type:
PROTEIN
Mol. Mass.:
24794.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_942634
Residue:
221
Sequence:
MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCECRHSPGRQSPDMPGDFRADAPSFLPPRRSLPMLFRMEWGCALTGSQSAVWPSSPVPEEIPRMHPGRNGKKQQRKPLREKMKPERCGDAVPRR
  
Inhibitor
Name:
BDBM50339209
Synonyms:
CHEMBL1689479
Type:
Small organic molecule
Emp. Form.:
C106H146N26O26S2
Mol. Mass.:
2264.582
SMILES:
CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(C)C |r,wU:4.3,64.68,49.56,2.2,145.161,117.123,99.105,132.140,20.21,8.8,39.41,wD:56.60,100.108,106.112,136.149,35.102,30.136,(16.25,-25.17,;14.91,-25.94,;13.58,-25.18,;13.58,-23.65,;12.25,-25.96,;8.31,-28.23,;6.97,-27.45,;5.63,-28.2,;6.99,-25.91,;8.32,-25.16,;8.34,-23.62,;9.68,-22.88,;9.7,-21.35,;8.38,-20.56,;8.4,-19.02,;7.04,-21.32,;7.02,-22.85,;5.67,-25.12,;4.34,-25.88,;4.32,-27.42,;2.99,-25.09,;3.01,-23.56,;1.69,-22.77,;1.55,-21.25,;.05,-20.91,;-.73,-22.23,;.28,-23.39,;1.66,-25.86,;1.72,-27.35,;3.06,-28.09,;.35,-28.11,;.34,-29.66,;1.68,-30.47,;1.67,-32.03,;2.98,-32.85,;2.98,-34.39,;4.31,-35.17,;4.31,-36.71,;2.97,-37.47,;5.63,-37.48,;5.62,-39.03,;4.28,-39.79,;2.88,-39.16,;1.85,-40.3,;2.61,-41.64,;4.12,-41.32,;6.97,-36.72,;8.28,-37.49,;8.28,-39.03,;9.63,-36.73,;11.08,-37.21,;11.99,-35.97,;11.09,-34.73,;9.63,-35.2,;8.29,-34.44,;6.97,-35.21,;8.29,-32.9,;6.95,-32.14,;5.63,-32.92,;4.29,-32.16,;5.63,-34.46,;9.63,-32.12,;9.61,-30.59,;8.27,-29.83,;10.94,-29.81,;12.27,-30.58,;12.26,-32.12,;13.59,-32.89,;13.58,-34.45,;14.93,-35.23,;16.28,-34.46,;16.28,-32.9,;17.62,-35.24,;18.97,-34.47,;20.32,-35.25,;21.67,-34.47,;21.67,-32.91,;23.02,-35.25,;24.37,-34.48,;25.71,-35.27,;27.06,-34.49,;27.07,-32.93,;28.41,-32.16,;29.76,-32.94,;31.11,-32.16,;31.11,-30.6,;32.46,-32.94,;32.86,-34.44,;34.36,-34.04,;33.96,-32.54,;34.74,-31.19,;25.71,-32.15,;24.37,-32.93,;10.97,-28.26,;12.26,-27.51,;13.59,-28.26,;1.65,-35.17,;1.65,-36.69,;.32,-34.4,;-1.01,-35.17,;-1.01,-36.7,;-2.34,-37.47,;.32,-37.47,;-2.34,-34.38,;-2.34,-32.85,;-3.68,-35.17,;-5.01,-34.38,;-5.02,-32.85,;-6.35,-32.08,;-7.68,-32.86,;-9.01,-32.09,;-10.34,-32.86,;-11.68,-32.09,;-10.34,-34.39,;-6.35,-35.17,;-7.68,-34.4,;-6.34,-36.7,;-7.67,-37.47,;-7.66,-39.03,;-9,-39.81,;-10.35,-39.03,;-11.7,-39.82,;-11.71,-41.38,;-13.04,-42.16,;-10.33,-42.15,;-8.99,-41.36,;-9.01,-36.71,;-10.34,-37.48,;-9.01,-35.17,;-.97,-27.34,;-2.31,-28.09,;-2.31,-29.63,;-3.65,-27.34,;-5,-28.1,;-6.31,-27.35,;-6.32,-25.82,;-7.67,-28.12,;-7.65,-29.66,;-8.97,-30.44,;-10.31,-29.69,;-11.64,-30.47,;-10.32,-28.16,;-8.97,-27.36,;-8.96,-25.83,;-7.63,-25.06,;-10.29,-25.05,;-10.28,-23.51,;-8.94,-22.75,;-7.62,-23.53,;-6.29,-22.76,;-6.28,-21.23,;-7.61,-20.46,;-8.94,-21.22,;-11.63,-25.81,;-12.98,-25.03,;-14.33,-25.81,;-12.98,-23.48,;-3.66,-25.8,;-4.99,-25.03,;-2.33,-25.03,)|
Structure:
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