Reaction Details
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Proteinase-activated receptor 2
Ligand
BDBM50339246
Substrate
n/a
Meas. Tech.
ChEMBL_736225 (CHEMBL1693369)
EC50
840±n/a nM
Citation
Boitano, S; Flynn, AN; Schulz, SM; Hoffman, J; Price, TJ; Vagner, J Potent agonists of the protease activated receptor 2 (PAR2). J Med Chem 54:1308-13 (2011) [PubMed] Article More Info.:
Target
Name:
Proteinase-activated receptor 2
Synonyms:
F2RL1 | GPR11 | PAR2 | PAR2_HUMAN
Type:
PROTEIN
Mol. Mass.:
44152.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1497756
Residue:
397
Sequence:
MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
Inhibitor
Name:
BDBM50339246
Synonyms:
CHEMBL1689558 | allyl(3S,6S,12S,15S,18S)-6-sec-butyl-18-carbamoyl-1-(furan-2-yl)-12-(3-guanidinopropyl)-3,15-diisobutyl-1,4,7,10,13,16-hexaoxo-2,5,8,11,14,17-hexaazahenicosan-21-ylcarbamate
Type:
Small organic molecule
Emp. Form.:
C40H67N11O10
Mol. Mass.:
862.0277
SMILES:
[#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-c1ccco1)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#8]-[#6]-[#6]=[#6])-[#6](-[#7])=O |r|
Structure:
