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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50339384
Substrate
n/a
Meas. Tech.
ChEMBL_736488 (CHEMBL1694433)
IC50
175000±n/a nM
Citation
 Hardcastle, IR; Liu, J; Valeur, E; Watson, A; Ahmed, SU; Blackburn, TJ; Bennaceur, K; Clegg, W; Drummond, C; Endicott, JA; Golding, BT; Griffin, RJ; Gruber, J; Haggerty, K; Harrington, RW; Hutton, C; Kemp, S; Lu, X; McDonnell, JM; Newell, DR; Noble, ME; Payne, SL; Revill, CH; Riedinger, C; Xu, Q; Lunec, J Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency. J Med Chem 54:1233-43 (2011) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM50339384
Synonyms:
(+/-)-3-(4-Chlorophenyl)-3-((1-(hydroxymethyl)cyclopropyl)methoxy)-2-(4-(methylthio)benzyl)isoindolin-1-one | CHEMBL1688289
Type:
Small organic molecule
Emp. Form.:
C27H26ClNO3S
Mol. Mass.:
480.018
SMILES:
CSc1ccc(CN2C(=O)c3ccccc3C2(OCC2(CO)CC2)c2ccc(Cl)cc2)cc1
Structure:
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