Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50306134
Substrate
n/a
Meas. Tech.
ChEMBL_735257 (CHEMBL1694519)
Ki
2±n/a nM
Citation
Watson, NS; Adams, C; Belton, D; Brown, D; Burns-Kurtis, CL; Chaudry, L; Chan, C; Convery, MA; Davies, DE; Exall, AM; Harling, JD; Irvine, S; Irving, WR; Kleanthous, S; McLay, IM; Pateman, AJ; Patikis, AN; Roethke, TJ; Senger, S; Stelman, GJ; Toomey, JR; West, RI; Whittaker, C; Zhou, P; Young, RJ The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs. Bioorg Med Chem Lett 21:1588-92 (2011) [PubMed] Article
More Info.:
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
Inhibitor
Name:
BDBM50306134
Synonyms:
6-chloro-N-((S)-1-(2-fluoro-4-((S)-1-(methylamino)ethyl)phenyl)-2-oxopyrrolidin-3-yl)naphthalene-2-sulfonamide | CHEMBL605294
Type:
Small organic molecule
Emp. Form.:
C23H23ClFN3O3S
Mol. Mass.:
475.963
SMILES:
CN[C@@H](C)c1ccc(N2CC[C@H](NS(=O)(=O)c3ccc4cc(Cl)ccc4c3)C2=O)c(F)c1 |r|