Reaction Details Report a problem with these data
Target
Prostaglandin D2 receptor 2
Ligand
BDBM50339763
Substrate
n/a
Meas. Tech.
ChEMBL_735530 (CHEMBL1693035)
IC50
39±n/a nM
Citation
 Luker, T; Bonnert, R; Paine, SW; Schmidt, J; Sargent, C; Cook, AR; Cook, A; Gardiner, P; Hill, S; Weyman-Jones, C; Patel, A; Thom, S; Thorne, P Zwitterionic CRTh2 antagonists. J Med Chem 54:1779-88 (2011) [PubMed]  Article 
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:
Enzyme
Mol. Mass.:
43295.45
Organism:
Homo sapiens (Human)
Description:
Q9Y5Y4
Residue:
395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
  
Inhibitor
Name:
BDBM50339763
Synonyms:
(S)-2-(4-chloro-2-((4-(2-(4-chlorophenyl)-2-methylpropanoyl)-3-methylpiperazin-1-yl)methyl)phenoxy)acetic acid | CHEMBL1689132
Type:
Small organic molecule
Emp. Form.:
C24H28Cl2N2O4
Mol. Mass.:
479.396
SMILES:
C[C@H]1CN(Cc2cc(Cl)ccc2OCC(O)=O)CCN1C(=O)C(C)(C)c1ccc(Cl)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: