Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50334342
Substrate
n/a
Meas. Tech.
ChEMBL_735540 (CHEMBL1693045)
Ki
8.9±n/a nM
Citation
 Pacchiano, F; Carta, F; McDonald, PC; Lou, Y; Vullo, D; Scozzafava, A; Dedhar, S; Supuran, CT Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis. J Med Chem 54:1896-902 (2011) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50334342
Synonyms:
4-(3-(2,3-dihydro-1H-inden-5-yl)ureido)benzenesulfonamide | 4-{[(2,3-dihydro-1H-inden-5-ylamino]carbonylamino)}benzenesulfonamide | CHEMBL1643307
Type:
Small organic molecule
Emp. Form.:
C16H17N3O3S
Mol. Mass.:
331.389
SMILES:
NS(=O)(=O)c1ccc(NC(=O)Nc2ccc3CCCc3c2)cc1
Structure:
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