Reaction Details Report a problem with these data
Target
Polyphenol oxidase 2
Ligand
BDBM33932
Substrate
n/a
Meas. Tech.
ChEMBL_739669 (CHEMBL1763495)
Ki
1700±n/a nM
Citation
 Ha, YM; Park, JY; Park, YJ; Park, D; Choi, YJ; Kim, JM; Lee, EK; Han, YK; Kim, JA; Lee, JY; Moon, HR; Chung, HY Synthesis and biological activity of hydroxy substituted phenyl-benzo[d]thiazole analogues for antityrosinase activity in B16 cells. Bioorg Med Chem Lett 21:2445-9 (2011) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM33932
Synonyms:
4-(3H-1,3-benzothiazol-2-ylidene)-1-cyclohexa-2,5-dienone | 4-(3H-1,3-benzothiazol-2-ylidene)cyclohexa-2,5-dien-1-one | CHEMBL47875 | MLS000773814 | SMR000364661 | cid_5351155
Type:
Small organic molecule
Emp. Form.:
C13H9NOS
Mol. Mass.:
227.282
SMILES:
Oc1ccc(cc1)-c1nc2ccccc2s1
Structure:
Search PDB for entries with ligand similarity: