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TargetSodium/glucose cotransporter 1 (SGLT1)
LigandBDBM20880
Substrate/Competitorn/a
Meas. Tech.ChEMBL_740119
IC50 370±n/a nM
Citation Li, ARZhang, JGreenberg, JLee, TLiu, J Discovery of non-glucoside SGLT2 inhibitors. Bioorg Med Chem Lett21:2472-5 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sodium/glucose cotransporter 1 (SGLT1)
Name:Sodium/glucose cotransporter 1 (SGLT1)
Synonyms:High affinity sodium-glucose cotransporter | Na(+)/glucose cotransporter 1 | Sodium-Dependent Glucose Cotransporter 1 (SGLT1) | Sodium-dependent glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 1
Type:Protein
Mol. Mass.:73503.78
Organism:Homo sapiens (Human)
Description:P13866
Residue:664
Sequence:
MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFL
AGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIY
IKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLA
IFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAI
PTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQR
CLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVG
CTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEK
ELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRV
NEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFIT
IVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKG
IFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCH
AYFA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM20880
NameBDBM20880
Synonyms:(2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-6-(hydroxymethyl)oxane-3,4,5-triol | BMS-512148 | C-aryl glucoside, 6 | CHEMBL429910 | Dapagliflozin
TypeSmall organic molecule
Emp. Form.C21H25ClO6
Mol. Mass.408.873
SMILESCCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a