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Target
SGLT1 protein
Ligand
BDBM50340014
Substrate
n/a
Meas. Tech.
ChEMBL_740123 (CHEMBL1763183)
IC50
3000±n/a nM
Citation
 Li, AR; Zhang, J; Greenberg, J; Lee, T; Liu, J Discovery of non-glucoside SGLT2 inhibitors. Bioorg Med Chem Lett 21:2472-5 (2011) [PubMed]  Article 
Target
Name:
SGLT1 protein
Synonyms:
Q9QXI6_MOUSE | SGLT1 protein | Sglt1 | Slc5a1 | Solute carrier family 5 (Sodium/glucose cotransporter), member 1 | Uncharacterized protein | sodium-dependent glucose cotransporter 1 (SGLT1)
Type:
Protein
Mol. Mass.:
73320.01
Organism:
Mus musculus (Mouse)
Description:
Q9QXI6
Residue:
665
Sequence:
MDSSTLSPAVTATDAPIPSYERIRNAADISVIVIYFVVVMAVGLWAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAAAGIAMGGFEWNALVLVVVLGWIFVPIYIKAGVVTMPEYLRKRFGGKRIQIYLSVLSLLLYIFTKISADIFSGAIFINLALGLDIYLAIFILLAITALYTITGGLAAVIYTDTLQTAIMLVGSFILTGFAFNEVGGYEAFMDKYMKAIPTKVSNGNFTAKEECYTPRADSFHIFRDPITGDMPWPGLIFGLAILALWYWCTDQVIVQRCLSAKNMSHVKAGCTLCGYLKLLPMFLMVMPGMISRILYTEKIACVLPEECQKYCGTPVGCTNIAYPTLVVELMPNGLRGLMLSVMMASLMSSLTSIFNSASTLFTMDIYTKIRKKASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEQGAFWGLILGFLIGISRMITEFAYGTGSCMEPSNCPKIICGVHYLYFAIILFVISVITILIISFLTKPIPDVHLYRLCWSLRNSKEERIDLDAGEEEDIPEDSKDTIEIDTEAPQKKKGCFRRAYDLFCGLDQDKGPKMTKEEEEAMKMKMTDTSEKPLWRTVVNINGIILLAVAVFCHAYFA
  
Inhibitor
Name:
BDBM50340014
Synonyms:
4-((5-(4-chlorobenzylthio)-4-methyl-4H-1,2,4-triazol-3-yl)methyl)-6-(trifluoromethyl)-2H-benzo[b][1,4]thiazin-3(4H)-one | CHEMBL1762483
Type:
Small organic molecule
Emp. Form.:
C20H16ClF3N4OS2
Mol. Mass.:
484.945
SMILES:
Cn1c(CN2C(=O)CSc3ccc(cc23)C(F)(F)F)nnc1SCc1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: