Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50340052
Substrate
n/a
Meas. Tech.
ChEMBL_739869 (CHEMBL1762929)
Ki
0.3±n/a nM
Citation
 Harris, JM; Neustadt, BR; Zhang, H; Lachowicz, J; Cohen-Williams, M; Varty, G; Hao, J; Stamford, AW Potent and selective adenosine A(2A) receptor antagonists: [1,2,4]-triazolo[4,3-c]pyrimidin-3-ones. Bioorg Med Chem Lett 21:2497-501 (2011) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50340052
Synonyms:
5-amino-2-benzyl-7-vinyl-2H-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidin-3(7H)-one | CHEMBL1762510
Type:
Small organic molecule
Emp. Form.:
C15H13N7O
Mol. Mass.:
307.31
SMILES:
Nc1nc2n(C=C)ncc2c2nn(Cc3ccccc3)c(=O)n12
Structure:
Search PDB for entries with ligand similarity: