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Target
Polyphenol oxidase 2
Ligand
BDBM50247599
Substrate
n/a
Meas. Tech.
ChEMBL_739884 (CHEMBL1762944)
IC50
10060000±n/a nM
Citation
 Liu, J; Wu, F; Chen, L; Hu, J; Zhao, L; Chen, C; Peng, L Evaluation of dihydropyrimidin-(2H)-one analogues and rhodanine derivatives as tyrosinase inhibitors. Bioorg Med Chem Lett 21:2376-9 (2011) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50247599
Synonyms:
(Z)-5-(4'-Hydroxybenzylidene)-2-thioxothiazolidin-4-one | 5-(4-hydroxybenzylidene)-2-thioxothiazolidin-4-one | CHEMBL487697
Type:
Small organic molecule
Emp. Form.:
C10H7NO2S2
Mol. Mass.:
237.298
SMILES:
Oc1ccc(C=C2SC(S)=NC2=O)cc1 |w:5.4,c:9|
Structure:
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