Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50340422
Substrate
n/a
Meas. Tech.
ChEMBL_741046 (CHEMBL1764274)
pH
7.4±n/a
IC50
0.03±n/a nM
Comments
extracted
Citation
Aspiotis, R; Chen, A; Cauchon, E; Dubé, D; Falgueyret, JP; Gagné, S; Gallant, M; Grimm, EL; Houle, R; Juteau, H; Lacombe, P; Laliberté, S; Lévesque, JF; MacDonald, D; McKay, D; Percival, MD; Roy, P; Soisson, SM; Wu, T The discovery and synthesis of potent zwitterionic inhibitors of renin. Bioorg Med Chem Lett 21:2430-6 (2011) [PubMed] Article
More Info.:
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Inhibitor
Name:
BDBM50340422
Synonyms:
(3R,4S)-N-(3-((1-((2H-tetrazol-5-yl)methyl)cyclopropyl)methoxy)-5-(3-methoxypropyl)benzyl)-N-cyclopropyl-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)piperidine-3-carboxamide | CHEMBL1761674
Type:
Small organic molecule
Emp. Form.:
C41H50Cl2N6O5
Mol. Mass.:
777.779
SMILES:
COCCCc1cc(CN(C2CC2)C(=O)[C@H]2CNCC[C@@H]2c2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)cc(OCC2(Cc3nnn[nH]3)CC2)c1 |r|