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Target
Transcription factor Jun
Ligand
BDBM50340600
Substrate
n/a
Meas. Tech.
ChEMBL_739507 (CHEMBL1763333)
IC50
120±n/a nM
Citation
 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) inhibitors. Bioorg Med Chem Lett 21:1719-23 (2011) [PubMed]  Article 
Target
Name:
Transcription factor Jun
Synonyms:
AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Type:
n/a
Mol. Mass.:
35683.24
Organism:
Homo sapiens (Human)
Description:
P05412
Residue:
331
Sequence:
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
  
Inhibitor
Name:
BDBM50340600
Synonyms:
CHEMBL1761555 | N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)-7-(1H-pyrazol-4-yl)quinazolin-2-amine
Type:
Small organic molecule
Emp. Form.:
C23H21N9O
Mol. Mass.:
439.4725
SMILES:
C1CN(CCO1)c1ncn(n1)-c1ccc(Nc2ncc3ccc(cc3n2)-c2cn[nH]c2)cc1
Structure:
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