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Target
Thymidylate synthase
Ligand
BDBM50340677
Substrate
n/a
Meas. Tech.
ChEMBL_740133 (CHEMBL1763193)
IC50
20±n/a nM
Citation
 Tzioumaki, N; Manta, S; Tsoukala, E; Vande Voorde, J; Liekens, S; Komiotis, D; Balzarini, J Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase. Eur J Med Chem 46:993-1005 (2011) [PubMed]  Article 
Target
Name:
Thymidylate synthase
Synonyms:
TS | TSase | TYSY_MOUSE | Tyms
Type:
PROTEIN
Mol. Mass.:
34957.15
Organism:
Mus musculus
Description:
ChEMBL_1340097
Residue:
307
Sequence:
MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPTIKMEMAV
  
Inhibitor
Name:
BDBM50340677
Synonyms:
(5-fluorouracil)5-Fluoro-1H-pyrimidine-2,4-dione | 5 fluorouracil | 5-FU | 5-Florouracil | 5-Fluoro-1H-pyrimidine-2,4-dione | 5-Fluoro-1H-pyrimidine-2,4-dione (5-FU) | 5-Fluoro-1H-pyrimidine-2,4-dione (5-Fluorouracil) | 5-Fluoro-1H-pyrimidine-2,4-dione(5-FU) | 5-Fluoro-1H-pyrimidine-2,4-dione(5-FUra) | 5-Fluoro-1H-pyrimidine-2,4-dione(5-fluoro uracil) | 5-Fluoro-1H-pyrimidine-2,4-dione(5-fluorouracil)(5-FU) | 5-Fluoro-1H-pyrimidine-2,4-dione(5FU) | 5-Fluorouracil | 5-fluoro-uracil | 5-fluoropyrimidine-2,4(1H,3H)-dione | 5-fluorouacil | 5-fluorourasil | 5F-uracil | Adrucil | CHEMBL185 | Carac | Efudex | FLUOROURACIL, 5- | Fluoroplex | Fluracil | Ro-2-9757
Type:
Small organic molecule
Emp. Form.:
C4H3FN2O2
Mol. Mass.:
130.0772
SMILES:
Fc1c[nH]c(=O)[nH]c1=O
Structure:
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