Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50340725
Substrate
n/a
Meas. Tech.
ChEMBL_740243 (CHEMBL1764143)
Ki
0.2±n/a nM
Citation
 Ivachtchenko, AV; Golovina, ES; Kadieva, MG; Koryakova, AG; Mitkin, OD; Tkachenko, SE; Kysil, VM; Okun, I 2-Substituted 5,6-dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines: new series of highly potent and specific serotonin 5-HT6 receptor antagonists. Eur J Med Chem 46:1189-97 (2011) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50340725
Synonyms:
CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidin-2-amine | US8829009, 1.1(1)
Type:
Small organic molecule
Emp. Form.:
C15H16N4O2S
Mol. Mass.:
316.378
SMILES:
CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Structure:
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