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Target
Bombesin receptor subtype-3
Ligand
BDBM50340977
Substrate
n/a
Meas. Tech.
ChEMBL_740068 (CHEMBL1763128)
EC50
>10000±n/a nM
Citation
 Lo, MM; Chobanian, HR; Palyha, O; Kan, Y; Kelly, TM; Guan, XM; Reitman, ML; Dragovic, J; Lyons, KA; Nargund, RP; Lin, LS Pyridinesulfonylureas and pyridinesulfonamides as selective bombesin receptor subtype-3 (BRS-3) agonists. Bioorg Med Chem Lett 21:2040-3 (2011) [PubMed]  Article 
Target
Name:
Bombesin receptor subtype-3
Synonyms:
BRS3_MOUSE | Brs3
Type:
PROTEIN
Mol. Mass.:
44239.49
Organism:
Mus musculus
Description:
ChEMBL_1445902
Residue:
399
Sequence:
MSQRQSQSPNQTLISITNDTETSSSVVSNDTTHKGWTGDNSPGIEALCAIYITYAGIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPPNAILKTCAKAGGIWIVSMIFALPEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYESYANHSDVPFVIIIFSRVLAFSNSCVNPFALYWLSKTFQQHFKAQLCCLKAEQPEPPLGDIPLNNLTVMGRVPATGSAHVSEISVTLFSGSSAKKGEDKV
  
Inhibitor
Name:
BDBM50340977
Synonyms:
CHEMBL1762260 | N-(tert-butylcarbamoyl)-4-(pyrrolidin-1-ylamino)pyridine-3-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C14H23N5O3S
Mol. Mass.:
341.429
SMILES:
CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NN1CCCC1
Structure:
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