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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50341149
Substrate
n/a
Meas. Tech.
ChEMBL_740363 (CHEMBL1764421)
EC50
2400±n/a nM
Citation
 Ushiroda, K; Maruta, K; Takazawa, T; Nagano, T; Taiji, M; Kohno, T; Sato, Y; Horai, S; Yanagi, K; Nagata, R Synthesis and pharmacological evaluation of novel benzoylazole-based PPARa/κ activators. Bioorg Med Chem Lett 21:1978-82 (2011) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50341149
Synonyms:
(E)-2-methyl-2-(3-(2-(2-(4-methylbenzoyl)-1H-benzo[d]imidazol-1-yl)vinyl)phenoxy)propanoic acid | CHEMBL1760559
Type:
Small organic molecule
Emp. Form.:
C27H24N2O4
Mol. Mass.:
440.4905
SMILES:
Cc1ccc(cc1)C(=O)c1nc2ccccc2n1\C=C\c1cccc(OC(C)(C)C(O)=O)c1
Structure:
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