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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50341311
Substrate
n/a
Meas. Tech.
ChEMBL_742671 (CHEMBL1769549)
Ki
1599±n/a nM
Citation
 McClure, KF; Darout, E; Guimarães, CR; DeNinno, MP; Mascitti, V; Munchhof, MJ; Robinson, RP; Kohrt, J; Harris, AR; Moore, DE; Li, B; Samp, L; Lefker, BA; Futatsugi, K; Kung, D; Bonin, PD; Cornelius, P; Wang, R; Salter, E; Hornby, S; Kalgutkar, AS; Chen, Y Activation of the G-protein-coupled receptor 119: a conformation-based hypothesis for understanding agonist response. J Med Chem 54:1948-52 (2011) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50341311
Synonyms:
(+/-)-isopropyl 8-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-6-oxa-3-azabicyclo[3.2.1]octane-3-carboxylate | CHEMBL1766083
Type:
Small organic molecule
Emp. Form.:
C21H26N4O5
Mol. Mass.:
414.4549
SMILES:
CC(C)OC(=O)N1CC2COC(C1)C2Oc1ncnc(Oc2cccnc2C)c1C
Structure:
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