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Target
Poly [ADP-ribose] polymerase 2
Ligand
BDBM50341859
Substrate
n/a
Meas. Tech.
ChEMBL_743712 (CHEMBL1767526)
IC50
90±n/a nM
Citation
 Sunderland, PT; Woon, EC; Dhami, A; Bergin, AB; Mahon, MF; Wood, PJ; Jones, LA; Tully, SR; Lloyd, MD; Thompson, AS; Javaid, H; Martin, NM; Threadgill, MD 5-Benzamidoisoquinolin-1-ones and 5-(κ-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2). J Med Chem 54:2049-59 (2011) [PubMed]  Article 
Target
Name:
Poly [ADP-ribose] polymerase 2
Synonyms:
2.4.2.- | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 2 | ADPRT-2 | ARTD2 | Adprt2 | Adprtl2 | Aspartl2 | DNA ADP-ribosyltransferase PARP2 | NAD(+) ADP-ribosyltransferase 2 | PARP-2 | PARP2_MOUSE | Parp2 | Poly (ADP-ribose) Polymerase-2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (Parp2) | Poly [ADP-ribose] polymerase-2 | Poly[ADP-ribose] synthase 2 | Poly[ADP-ribose] synthetase 2 | Protein poly-ADP-ribosyltransferase PARP2 | mPARP-2 | pADPRT-2 | poly-ADP-ribose polymerase 2 (PARP2)
Type:
n/a
Mol. Mass.:
63409.97
Organism:
Mus musculus (Mouse)
Description:
Alexis Biochemicals, Cat. no. ALX-201-064-C020
Residue:
559
Sequence:
MAPRRQRSGSGRRVLNEAKKVDNGNKATEDDSPPGKKMRTCQRKGPMAGGKDADRTKDNRDSVKTLLLKGKAPVDPECAAKLGKAHVYCEGDDVYDVMLNQTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKTGQHSLVTCSGDLNKAKEIFQKKFLDKTKNNWEDRENFEKVPGKYDMLQMDYAASTQDESKTKEEETLKPESQLDLRVQELLKLICNVQTMEEMMIEMKYDTKRAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALVEACNEFYTRIPHDFGLSIPPVIRTEKELSDKVKLLEALGDIEIALKLVKSERQGLEHPLDQHYRNLHCALRPLDHESNEFKVISQYLQSTHAPTHKDYTMTLLDVFEVEKEGEKEAFREDLPNRMLLWHGSRLSNWVGILSHGLRVAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAQGLLRGKHSTKGMGKMAPSPAHFITLNGSTVPLGPASDTGILNPEGYTLNYNEFIVYSPNQVRMRYLLKIQFNFLQLW
  
Inhibitor
Name:
BDBM50341859
Synonyms:
2-(4-chlorophenyl)quinoxaline-5-carboxamide | CHEMBL1767067
Type:
Small organic molecule
Emp. Form.:
C15H10ClN3O
Mol. Mass.:
283.712
SMILES:
NC(=O)c1cccc2nc(cnc12)-c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: