Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50239833
Substrate
n/a
Meas. Tech.
ChEMBL_743505 (CHEMBL1767946)
IC50
120±n/a nM
Citation
 Vintonyak, VVWaldmann, HRauh, D Using small molecules to target protein phosphatases. Bioorg Med Chem 19:2145-55 (2011) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50239833
Synonyms:
(3-bromo-7-cyanonaphthalen-2-yl)difluoromethylphosphonic acid | CHEMBL259628 | US10150787, Example 10 | US11597739, Example 10 | [(3-bromo-7-cyano-2-naphthyl)-(difluoro)methyl]phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C12H7BrF2NO3P
Mol. Mass.:
362.063
SMILES:
OP(O)(=O)C(F)(F)c1cc2cc(ccc2cc1Br)C#N
Structure:
Search PDB for entries with ligand similarity: